8/14/2023 0 Comments Supplements for covid brain fog![]() The build-up of adenosine and its binding with the adenosine receptor drives us to need to sleep each night, so the interaction with the adenosine receptor theoretically would only increase sleepiness at the end of the day (not making you sleepy during the day). Interestingly, this hypnotic effect was driven by interactions with the adenosine receptor. Luteolin and sleep:Īnimal studies show that luteolin has a sleep-inducing effect – at least when given with a sleep drug. Through protecting against inflammatory cytokine over-production, luteolin protects against oxidative stress in cells. IL-31 is an inflammatory cytokine produced by activated T lymphocytes, and it plays a role in chronic inflammatory diseases.Īll in all, the research shows luteolin as a specific anti-inflammatory to target elevated TNF, IL-6, IL-31, and IL-33. ![]() In microglial cells, luteolin and another flavonoid, apigenin, suppress IL-31 and IL-33.In other research, luteolin reduces IL-6 (interleukin 6), an inflammatory cytokine produced in response to bacterial infections.TNF-alpha and IL-6 are linked to many chronic diseases caused by elevated inflammatory cytokines. In cell studies, luteolin i nhibits TNF-alpha and IL-6 released via suppressing NF-κB.Research also shows that luteolin may reduce or prevent chronic inflammation. ![]() Keep in mind that mouse and cell studies don’t always pan out when it comes to Alzheimer’s research… but for luteolin, there is little risk and a lot of potential benefits. In a mouse study of Alzheimer’s, luteolin protects against amyloid β memory dysfunction and also increases levels of endogenous antioxidants, including Mn-SOD, Cu/Zn-SOD, and glutathione.Animal studies show luteolin inhibits neuroinflammation by controlling microglia activation.Luteolin selectively inhibits the type of O-glycosylation (Mucin-type O-glycosylation) involved in the formation of amyloid-β.Let me be clear: this is purely theoretical and has not been confirmed in human investigations. Inhibiting this process could reduce amyloid in the brain, at least in theory. The creation of amyloid-beta, which builds up in plaques in Alzheimer’s sufferers’ brains, requires the O-glycosylation of the amyloid precursor protein. Neurodegenerative diseases such as Alzheimer’s: The mechanism of how luteolin could help seems logical, but there aren’t any clinical trials on luteolin for Long Covid (yet). Some researchers think that luteolin may help with brain fog, or cognitive issues, in long Covid. Other research explains that luteolin may help specifically with “brain fog” by decreasing neuroinflammation. Luteolin decreases the cytokines that cause inflammation in the brain. Studies show that luteolin may help with cognitive dysfunction caused by inflammation. This is important since a lot of research studies only show very minor benefits that aren’t really meaningful. Research shows that luteolin may have clinically meaningful neuroprotective effects. Related article: Brain Fog and Genetics Neuroprotective effects of luteolin: The researchers believe that luteolin can help with brain fog, citing studies that show it can improve focus in children with autism. According to some researchers, inflammation along with histamine release causes brain fog in people with mast cell activation disorders. The ‘brain fog’ term applies to the inability to think clearly or concentrate. Several mast cell researchers and clinicians recommend luteolin for preventing mast cell degranulation. This may benefit anyone dealing with mast cell activation syndrome (MCAS) or histamine intolerance. Research shows that luteolin can act as a mast cell stabilizer and reduce histamine release. Luteolin as an antihistamine and mast cell stabilizer: lutein: Luteolin is not to be confused with lutein, a plant pigment that can help with macular degeneration. Be sure to check the reviews for any supplement you choose. Normal dosages range from 100 mg – 500 mg in dried herb or liposomal forms, however, most supplements and studies are in the 100 mg range. ![]() Parsley, carrots, artichokes, celery, thyme, chamomile tea, olive oil, oranges, green peppers, and oregano contain the flavone luteolin.Īs a natural herbal supplement, luteolin is readily available at health food stores and online (e.g. Many of these plant molecules also bring health benefits to us when we consume them. ![]() Plants produce flavonoids, such as luteolin, as a cellular defense against pathogens or UV radiation. Luteolin is a flavonoid found in small amounts in several herbs and vegetables. Luteolin: Benefits, foods, and supplement options
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